Five prodrugs of S(+)-2-(6-methoxy-2-naphthyl)propionic acid (naproxen), in which the drug was bound by ester linkages to diethyleneglycol (I), triethyleneglycol (II), octanediol (III), butyl-triethyleneglycol (IV), and butyl-tetraethyleneglycol (V), respectively, were prepared and tested for their pharmacokinetic properties after oral administration. It was found that bioavailabilities decreased in the order, and in all cases were lower than that of the free drug.
|Titolo:||PHARMACOKINETIC RESULTS ON NAPROXEN PRODRUGS BASED ON POLY(ETHYLENEGLYCOL)S|
RANUCCI, ELISABETTA (Primo)
|Settore Scientifico Disciplinare:||Settore CHIM/04 - Chimica Industriale|
|Data di pubblicazione:||1994|
|Digital Object Identifier (DOI):||10.1163/156856294X00275|
|Appare nelle tipologie:||01 - Articolo su periodico|