New monofunctionalized amphiphilic oligomers, poly (N-vinyl pyrrolidinones) with an hydroxyl end group, were prepared by radical polymerization with 2-isopropoxyethanol, fractionated by both gel-permeation chromatography and fractional precipitation. The terminal hydroxyl group oligomers was activated and reacted with the amino groups of a model peptide, and a protein. These hydroxylated oligomers were also converted to carboxylate end group which were also activated and used as protein and peptide modifying agents.
|Titolo:||LOW-MOLECULAR-WEIGHT END-FUNCTIONALIZED POLY(N-VINYLPYRROLIDINONE) FOR THE MODIFICATION OF POLYPEPTIDE AMINOGROUPS|
|Settore Scientifico Disciplinare:||Settore CHIM/04 - Chimica Industriale|
|Data di pubblicazione:||1994|
|Digital Object Identifier (DOI):||10.1177/088391159400900404|
|Appare nelle tipologie:||01 - Articolo su periodico|