New monofunctionalized amphiphilic oligomers, poly (N-vinyl pyrrolidinones) with an hydroxyl end group, were prepared by radical polymerization with 2-isopropoxyethanol, fractionated by both gel-permeation chromatography and fractional precipitation. The terminal hydroxyl group oligomers was activated and reacted with the amino groups of a model peptide, and a protein. These hydroxylated oligomers were also converted to carboxylate end group which were also activated and used as protein and peptide modifying agents.

LOW-MOLECULAR-WEIGHT END-FUNCTIONALIZED POLY(N-VINYLPYRROLIDINONE) FOR THE MODIFICATION OF POLYPEPTIDE AMINOGROUPS / S. L., E. Ranucci, F. P, C. P., S. O., V. F.. - In: JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS. - ISSN 0883-9115. - 9:4(1994), pp. 411-428. [10.1177/088391159400900404]

LOW-MOLECULAR-WEIGHT END-FUNCTIONALIZED POLY(N-VINYLPYRROLIDINONE) FOR THE MODIFICATION OF POLYPEPTIDE AMINOGROUPS

E. Ranucci;
1994

Abstract

New monofunctionalized amphiphilic oligomers, poly (N-vinyl pyrrolidinones) with an hydroxyl end group, were prepared by radical polymerization with 2-isopropoxyethanol, fractionated by both gel-permeation chromatography and fractional precipitation. The terminal hydroxyl group oligomers was activated and reacted with the amino groups of a model peptide, and a protein. These hydroxylated oligomers were also converted to carboxylate end group which were also activated and used as protein and peptide modifying agents.
Settore CHIM/04 - Chimica Industriale
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/188450
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