Biocompatible polymers with specific shape and tailored hydrogel properties were obtained by polymerization of mixtures of 2-hydroxyethyl methacrylate (HEMA) with 1-8 wt % ethylene glycol dimethacrylate (EGDMA) or tetra(ethylene glycol) diacrylate (TEGDA) as crosslinking agents, by using a redox initiator. Introduction of charged positive and negative groups was easily achieved by direct polymerization of appropriate monomer mixtures and by chemical transformation of preformed hydrogels. Investigation of the swelling behavior of the prepared hydrogels evidenced an appreciable dependence on both solvent type and polymer chemical structure. Additionally, the solvation process resulted in being controlled by solvent diffusion, according to a Fickian II mechanism. The presence of several types of water with different melting behavior was observed in fully swollen hydrogels.

Bioerodible hydrogels based on 2-hydroxyethyl methacrylate: synthesis and characterization. / Chielini F., Petrucci F., E. RANUCCI E., Solaro R.. - In: JOURNAL OF APPLIED POLYMER SCIENCE. - ISSN 0021-8995. - 85:13(2002), pp. 2729-2741.

Bioerodible hydrogels based on 2-hydroxyethyl methacrylate: synthesis and characterization.

E. RANUCCI E.;
2002

Abstract

Biocompatible polymers with specific shape and tailored hydrogel properties were obtained by polymerization of mixtures of 2-hydroxyethyl methacrylate (HEMA) with 1-8 wt % ethylene glycol dimethacrylate (EGDMA) or tetra(ethylene glycol) diacrylate (TEGDA) as crosslinking agents, by using a redox initiator. Introduction of charged positive and negative groups was easily achieved by direct polymerization of appropriate monomer mixtures and by chemical transformation of preformed hydrogels. Investigation of the swelling behavior of the prepared hydrogels evidenced an appreciable dependence on both solvent type and polymer chemical structure. Additionally, the solvation process resulted in being controlled by solvent diffusion, according to a Fickian II mechanism. The presence of several types of water with different melting behavior was observed in fully swollen hydrogels.
2-hydroxyethyl methacrylate; Biomaterials; Diffusion; Hydrogels; Water structure
Settore CHIM/04 - Chimica Industriale
2002
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/188441
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