Anatomical and biochemical studies have identified a hypothalamic tubero-infundibular GABAergic system, which plays a functional role on anterior pituitary hormone secretion. Experimental and clinical evidence support the presence of a dual component in the action of GABA; one mediated via the central nervous system and the other exerted directly at the anterior pituitary level. The two sites of action may be responsible for the excitatory and inhibitory effects of GABA on pituitary hormone and especially prolactin secretion. The future characterization of this system will provide a better understanding of the involvement of GABA in the physiology of anterior pituitary hormone secretion and will contribute to the developent of new pharmacological agents for the therapy of neuroendocrine disorders.

GABAERGIC CONTROL OF ANTERIOR PITUITARY HORMONE SECRETION / G.A. RACAGNI, J.A. APUD, D. COCCHI, V. LOCATELLI, E.E. MULLER. - In: LIFE SCIENCES. - ISSN 0024-3205. - 31:9(1982), pp. 823-838.

GABAERGIC CONTROL OF ANTERIOR PITUITARY HORMONE SECRETION

G.A. RACAGNI
Primo
;
E.E. MULLER
Ultimo
1982

Abstract

Anatomical and biochemical studies have identified a hypothalamic tubero-infundibular GABAergic system, which plays a functional role on anterior pituitary hormone secretion. Experimental and clinical evidence support the presence of a dual component in the action of GABA; one mediated via the central nervous system and the other exerted directly at the anterior pituitary level. The two sites of action may be responsible for the excitatory and inhibitory effects of GABA on pituitary hormone and especially prolactin secretion. The future characterization of this system will provide a better understanding of the involvement of GABA in the physiology of anterior pituitary hormone secretion and will contribute to the developent of new pharmacological agents for the therapy of neuroendocrine disorders.
Settore BIO/14 - Farmacologia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/188379
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