Supported lipase from Candida antarctica (Chirazyme((R))) was employed for a regioselective protection of the 2-azido derivatives 1 and 2, synthetic equivalents of beta-(D)-Gal(1 ->3)-(D)-GlcNAc and beta-(D)-Gal(1->4)-(D-)GlcNAc (N-acetyl lactosamine), respectively. The selectivity of the enzyme towards 1 and 2 was also exploited for an easy separation of the mixture of the two compounds obtained from a straightforward synthetic approach. (C) 2000 Elsevier Science Ltd. All rights reserved.
Regioselective lipase acylation as a useful tool for separation and selective protection of beta-D-Gal(1 -> 4)-D-GlcNAc and beta-D-Gal(1 -> 3)-D-GlcNAc disaccharides / B. La Ferla, L. Lay, G. Russo, L. Panza. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 11:18(2000), pp. 3647-3651. [10.1016/S0957-4166(00)00342-6]
Regioselective lipase acylation as a useful tool for separation and selective protection of beta-D-Gal(1 -> 4)-D-GlcNAc and beta-D-Gal(1 -> 3)-D-GlcNAc disaccharides
L. LaySecondo
;G. RussoPenultimo
;
2000
Abstract
Supported lipase from Candida antarctica (Chirazyme((R))) was employed for a regioselective protection of the 2-azido derivatives 1 and 2, synthetic equivalents of beta-(D)-Gal(1 ->3)-(D)-GlcNAc and beta-(D)-Gal(1->4)-(D-)GlcNAc (N-acetyl lactosamine), respectively. The selectivity of the enzyme towards 1 and 2 was also exploited for an easy separation of the mixture of the two compounds obtained from a straightforward synthetic approach. (C) 2000 Elsevier Science Ltd. All rights reserved.
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