This viewpoint proposes that an imbalance in the T(H)1-type and T(H)2-type responses contributes to the immune dysregulation associated with HIV infection, and that resistance to HIV infection and/or progression to AIDS is dependent on a T(H)1 > T(H)2 dominance. This hypothesis is based on the authors' findings that: (1) progression to AIDS is characterized by loss of IL-2- and IFN-gamma production concomitant with increases in IL-4 and IL-10; and (2) many seronegative, HIV-exposed individuals generate strong T(H)1-type responses to HIV antigens.

A TH1-->TH2 switch is a critical step in the etiology of HIV infection / M. Clerici, G.M. Shearer. - In: IMMUNOLOGY TODAY. - ISSN 0167-5699. - 14:3(1993), pp. 107-110.

A TH1-->TH2 switch is a critical step in the etiology of HIV infection

M. Clerici
Primo
;
1993

Abstract

This viewpoint proposes that an imbalance in the T(H)1-type and T(H)2-type responses contributes to the immune dysregulation associated with HIV infection, and that resistance to HIV infection and/or progression to AIDS is dependent on a T(H)1 > T(H)2 dominance. This hypothesis is based on the authors' findings that: (1) progression to AIDS is characterized by loss of IL-2- and IFN-gamma production concomitant with increases in IL-4 and IL-10; and (2) many seronegative, HIV-exposed individuals generate strong T(H)1-type responses to HIV antigens.
human-immunodeficiency-virus; T-helper-cell; cytokine production; type-1; individuals; responses; antigen; invitro; abnormalities; interleukin-2
Settore MED/04 - Patologia Generale
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/188242
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