The aim of this research was to investigate endogenous concentrations and anti-cytokine effects of the antiinflammatory peptide alpha-melanocyte stimulating hormone (alpha-MSH) in patients with systemic inflammation. The objectives were to determine the following: changes over time of plasma alpha-MSH and relationship with patient outcome, correlation between plasma alpha-MSH and tumor necrosis factor (TNF)-alpha plasma concentration and production in whole blood samples, and influences of alpha-MSH on production of TNF-alpha and interleukin (IL)-1beta in whole blood samples stimulated with lipopolysaccharide (LPS).
|Titolo:||Plasma concentrations and anti-L-cytokine effects of alpha-melanocyte stimulating hormone in septic patients|
GATTINONI, LUCIANO (Ultimo)
|Parole Chiave:||α-melanocyte stimulating hormone; Cytokine production; Interleukin-1; Lipopolysaccharide; Sepsis syndrome; Septic shock; Systemic inflammation; Tumor necrosis factor-α; Whole blood|
|Settore Scientifico Disciplinare:||Settore MED/41 - Anestesiologia|
|Data di pubblicazione:||mag-2000|
|Appare nelle tipologie:||01 - Articolo su periodico|