The aim of this research was to investigate endogenous concentrations and anti-cytokine effects of the antiinflammatory peptide alpha-melanocyte stimulating hormone (alpha-MSH) in patients with systemic inflammation. The objectives were to determine the following: changes over time of plasma alpha-MSH and relationship with patient outcome, correlation between plasma alpha-MSH and tumor necrosis factor (TNF)-alpha plasma concentration and production in whole blood samples, and influences of alpha-MSH on production of TNF-alpha and interleukin (IL)-1beta in whole blood samples stimulated with lipopolysaccharide (LPS).
Plasma concentrations and anti-L-cytokine effects of alpha-melanocyte stimulating hormone in septic patients / A. Catania, M. Cutuli, L. Garofalo, L. Airaghi, F. Valenza, J. M. Lipton, L. Gattinoni. - In: CRITICAL CARE MEDICINE. - ISSN 0090-3493. - 28:5(2000 May), pp. 1403-7-1407.
Plasma concentrations and anti-L-cytokine effects of alpha-melanocyte stimulating hormone in septic patients
F. Valenza;L. GattinoniUltimo
2000
Abstract
The aim of this research was to investigate endogenous concentrations and anti-cytokine effects of the antiinflammatory peptide alpha-melanocyte stimulating hormone (alpha-MSH) in patients with systemic inflammation. The objectives were to determine the following: changes over time of plasma alpha-MSH and relationship with patient outcome, correlation between plasma alpha-MSH and tumor necrosis factor (TNF)-alpha plasma concentration and production in whole blood samples, and influences of alpha-MSH on production of TNF-alpha and interleukin (IL)-1beta in whole blood samples stimulated with lipopolysaccharide (LPS).
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