The effects of subcutaneous pretreatment with the glucocorticoid/progesterone receptor antagonist RU 486 on the antinociceptive action of peripherally administered morphine were evaluated by the hot-plate test in mice. The steroid significantly reduced the analgesic effect of the opiate. Neither dexamethasone nor progesterone modified the effects of RU 486 on morphine-induced analgesia. Therefore, the present data indicate that the modulatory effect of RU 486 on morphine-induced analgesia does not involve the binding of this drug to classical steroid receptors.

RU 486 reduces morphine-induced analgesia in mice, but steroid receptors are not involved / M. Bianchi, R. Maggi, A. E. Panerai, L. Martini. - In: PHARMACOLOGY. - ISSN 0031-7012. - 52:6(1996 Jun), pp. 387-391.

RU 486 reduces morphine-induced analgesia in mice, but steroid receptors are not involved

M. Bianchi;R. Maggi;A. E. Panerai;L. Martini
1996

Abstract

The effects of subcutaneous pretreatment with the glucocorticoid/progesterone receptor antagonist RU 486 on the antinociceptive action of peripherally administered morphine were evaluated by the hot-plate test in mice. The steroid significantly reduced the analgesic effect of the opiate. Neither dexamethasone nor progesterone modified the effects of RU 486 on morphine-induced analgesia. Therefore, the present data indicate that the modulatory effect of RU 486 on morphine-induced analgesia does not involve the binding of this drug to classical steroid receptors.
Dexamethasone; Animals; Morphine; Drug Interactions; Analgesia; Progesterone; Injections, Subcutaneous; Pain Measurement; Receptors, Steroid; Mifepristone; Mice; Male
Settore BIO/09 - Fisiologia
Settore BIO/14 - Farmacologia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/188019
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