We have evaluated the intrafamilial transmission of hepatitis C virus (HCV) by studying 1) the 107 household contacts of 43 patients with chronic HCV liver disease, 2) the household contacts of 30 anti-HCV-positive donors without liver disease, and 3) 3108 blood donors. We also studied the possible manner of the intrafamilial transmission. The prevalence of anti-HCV positivity in the families of index patients was significantly higher than in donors (14.9% as against to 1.7% All the family members of the anti-HCV-positive donors were anti-HCV negative. We conclude that the person-to-person transmission of HCV is possible and most probable in contacts of anti-HCV-positive patients with liver disease.
High prevalence of antibodies to hepatitis C virus among family members of patients with anti-HCV positive chronic liver disease / E. BUSCARINI, E. TANZI, A.R. ZANETTI, E. SAVI, G. SBOLLI, G. CIVARDI, M. DI STASI, F. FORNARI, L. BUSCARINI. - In: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. - ISSN 0036-5521. - 28:4(1993), pp. 343-346.
High prevalence of antibodies to hepatitis C virus among family members of patients with anti-HCV positive chronic liver disease
E. TANZISecondo
;A.R. ZANETTI;
1993
Abstract
We have evaluated the intrafamilial transmission of hepatitis C virus (HCV) by studying 1) the 107 household contacts of 43 patients with chronic HCV liver disease, 2) the household contacts of 30 anti-HCV-positive donors without liver disease, and 3) 3108 blood donors. We also studied the possible manner of the intrafamilial transmission. The prevalence of anti-HCV positivity in the families of index patients was significantly higher than in donors (14.9% as against to 1.7% All the family members of the anti-HCV-positive donors were anti-HCV negative. We conclude that the person-to-person transmission of HCV is possible and most probable in contacts of anti-HCV-positive patients with liver disease.Pubblicazioni consigliate
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