We have studied the phosphorylation system associated with the rat cerebrocortical microtubule fraction after short- and long-term administration (15 mg/kg) of fluvoxamine, a selective serotonin reuptake inhibitor with antidepressant activity. Fluvoxamine administered for 5 days significantly enhanced the P-32 incorporation stimulated by cAMP into MAP2, while it failed to produce this effect after 12 and 21 days. Moreover, in the same periods of treatment no changes were observed in basal phosphorylation and in the pattern of microtubule proteins. In conclusion, our results suggest that changes in the protein phosphorylation system associated with the microtubule fraction could represent an early neurochemical modification involved in the action of fluvoxamine.
Effects of fluvoxamine on the protein phosphorylation system associated with rat neuronal microtubules / J. Perez, S. Mori, M. Caivano, M. Popoli, R. Zanardi, E. Smeraldi, G. Racagni. - In: EUROPEAN NEUROPSYCHOPHARMACOLOGY. - ISSN 0924-977X. - 5:Suppl. 1(1995), pp. 65-69. ((Intervento presentato al convegno International Meeting on Major Psychoses : Biological and Therapeutic Aspects of Major Psychoses tenutosi a Cagliari nel 1994.
|Titolo:||Effects of fluvoxamine on the protein phosphorylation system associated with rat neuronal microtubules|
RACAGNI, GIORGIO ANGELO (Ultimo)
|Parole Chiave:||Antidepressant; Fluvoxamine; Neuronal microtubule; Protein phosphorylation|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||1995|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/0924-977X(95)00024-J|
|Appare nelle tipologie:||01 - Articolo su periodico|