Abstract The authors enrolled 1,029 patients with CD4 counts </= 200/microL and no CNS AIDS-defining events (CNS-AIDS) between January 1993 and December 1998. The primary end point was the first appearance of CNS-AIDS. Three different periods and different antiretroviral regimens were considered. During the median follow-up of 329 days, 144 patients (9.5%) developed CNS-AIDS. The independent predictors were CD4 counts and therapy. All regimens decreased the risk of CNS-AIDS. Highly active antiretroviral therapy led to a 95% risk reduction in comparison with untreated patients.
Decreasing incidence of CNS AIDS-defining events associated with antiretroviral therapy. / A. d’Arminio Monforte, P.G. Duca, L. Vago, M.P. Grassi, M. Moroni.. - In: NEUROLOGY. - ISSN 0028-3878. - 54:9(2000 May 09), pp. 1856-1859.
Decreasing incidence of CNS AIDS-defining events associated with antiretroviral therapy.
A. d’Arminio MonfortePrimo
;P.G. DucaSecondo
;L. Vago;M. Moroni.Ultimo
2000
Abstract
Abstract The authors enrolled 1,029 patients with CD4 counts = 200/microL and no CNS AIDS-defining events (CNS-AIDS) between January 1993 and December 1998. The primary end point was the first appearance of CNS-AIDS. Three different periods and different antiretroviral regimens were considered. During the median follow-up of 329 days, 144 patients (9.5%) developed CNS-AIDS. The independent predictors were CD4 counts and therapy. All regimens decreased the risk of CNS-AIDS. Highly active antiretroviral therapy led to a 95% risk reduction in comparison with untreated patients.Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.