Native and reduced-carboxamidomethylated (RCM) HDL3 are incubated with a lipoprotein-depleted plasma fraction in the presence of triacylglycerol-rich particles isolated from Intralipid. Unmodified HDL3 are mainly converted into large HDL2b particles (diameter: 9.84 ± 0.15 nm); RCM-HDL3 are transformed into both large HDL2b (9.76 ± 0.10 nm) and small HDL3c (7.68 ± 0.07 nm). These findings indicate that the apo A-II dimers participate in the remodeling of HDL, by inhibiting the formation of small HDL particles.

APOLIPOPROTEIN-A-II MODULATES HDL REMODELING IN PLASMA / L. CALABRESI, C. BANFI, C. SIRTORI, G. FRANCESCHINI. - In: BIOCHIMICA ET BIOPHYSICA ACTA. - ISSN 0006-3002. - 1124:2(1992), pp. 195-198. [10.1016/0005-2760(92)90098-G]

APOLIPOPROTEIN-A-II MODULATES HDL REMODELING IN PLASMA

L. Calabresi
Primo
;
C. Sirtori
Penultimo
;
G. Franceschini
Ultimo
1992

Abstract

Native and reduced-carboxamidomethylated (RCM) HDL3 are incubated with a lipoprotein-depleted plasma fraction in the presence of triacylglycerol-rich particles isolated from Intralipid. Unmodified HDL3 are mainly converted into large HDL2b particles (diameter: 9.84 ± 0.15 nm); RCM-HDL3 are transformed into both large HDL2b (9.76 ± 0.10 nm) and small HDL3c (7.68 ± 0.07 nm). These findings indicate that the apo A-II dimers participate in the remodeling of HDL, by inhibiting the formation of small HDL particles.
Apolipoprotein A-II; HDL
Settore BIO/14 - Farmacologia
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/187848
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