Thrombosis is a key feature of the initiation and progression of atherosclerosis and its clinical sequelae. Acute thrombosis can lead to arterial occlusion and consequently provoke myocardial infarction, unstable angina, stroke and sudden death. Acute thrombosis can also be a complication of arterial bypass surgery, balloon angioplasty, atherectomy, or coronary artery stenting. The thrombotic response is influenced by several factors, among them the thrombogenicity of the vessel wall and of certain blood components as well as their interaction with the lipid pool. Tissue factor (TF) is considered to be the primary cofactor of cellular origin that is involved in activation of the coagulation pathway. The active form of TF has been shown to be present in specimens of human coronary artery in association both with acellular lipid areas and with macrophages and smooth muscle cells, which suggests that TF plays a major role in determining plaque thrombogenicity. We discuss here what is currently known about the role of tissue factor in atherogenesis, and focus attention on pharmacological approaches in this area.
Tissue factor in atherosclerosis / E. Tremoli, M. Camera, V. Toschi, S. Colli. - In: ATHEROSCLEROSIS. - ISSN 0021-9150. - 144:2(1999 Jun), pp. 273-283.
|Titolo:||Tissue factor in atherosclerosis|
TREMOLI, ELENA (Primo)
CAMERA, MARINA (Secondo)
COLLI, SUSANNA (Ultimo)
|Parole Chiave:||Acute coronary syndromes; Atheroma; Atherosclerosis; Plaque cellularity; Plaque thrombogenicity; Thrombosis; Tissue factor|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||giu-1999|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/S0021-9150(99)00063-5|
|Appare nelle tipologie:||01 - Articolo su periodico|