Gangliosides that contain the disialosyl residue α-Neu5Ac-(2→8)-α-Neu5Ac-(2→3)- can lactonize in the presence of traces of acid and this reaction has been studied in detail on GD1b {β-Gal-(1→3)-β-GalNAc-(1→4)-[α-Neu5Ac-(2→8)-α-Neu5Ac-(2→3)]-β-Gal-(1→4)-β-Glc-(1→1)-Cer}. Lactonization occurs rapidly at a proton-ganglioside molar ratio of ≫1. At equilibrium, the ratio of GD1b to its lactone is 3:7. The data suggest the possibility that a proton-driven lactonization of gangliosides may occur in vivo.
LACTONIZATION OF GD1B GANGLIOSIDE UNDER ACIDIC CONDITIONS / R. BASSI, L. RIBONI, S. SONNINO, G. TETTAMANTI. - In: CARBOHYDRATE RESEARCH. - ISSN 0008-6215. - 193:C(1989), pp. 141-146.
Titolo: | LACTONIZATION OF GD1B GANGLIOSIDE UNDER ACIDIC CONDITIONS | |
Autori: | BASSI, ROSARIA (Primo) RIBONI, LAURA PIERA CARLA GIULIA (Secondo) SONNINO, SANDRO (Penultimo) TETTAMANTI, GUIDO (Ultimo) | |
Settore Scientifico Disciplinare: | Settore BIO/10 - Biochimica | |
Data di pubblicazione: | 1989 | |
Rivista: | ||
Tipologia: | Article (author) | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/0008-6215(89)85113-4 | |
Appare nelle tipologie: | 01 - Articolo su periodico |