When monoamine oxidase B (MAO B) from rat liver mitochondria was incubated with MPTP, methylamine was formed and MAO B was inactivated. Incubation of 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP+) with MAO B also yielded methylamine and resulted in inactivation of the enzyme. Similar rate consts. for inactivation of MAO B were obtained with 1-methyl-4-phenyl-1,4-dihydropyridine, 3-phenylglutaraldehyde (3-PG), and 2,6-dihydroxy-4-phenyltetrahydropyran, suggesting that bioalkylation of the enzyme occurs outside the active site via a species such as 3-PG.
|Titolo:||Mechanistic studies on the MPTP inactivation of MAO B|
SPARATORE, ANNA CONCETTINA (Secondo)
|Parole Chiave:||monoamine oxidase B inactivation; MPTP and its metabolites;|
|Settore Scientifico Disciplinare:||Settore CHIM/08 - Chimica Farmaceutica|
|Data di pubblicazione:||1987|
|Appare nelle tipologie:||01 - Articolo su periodico|