Opioid receptor like-1 (ORL-1) has recently been indicated as a potentially useful target for the treatment of a number of central disorders and several other diseases. This review deals with non peptidic ligands at the ORL-1 receptor, focusing on their structural and binding properties. Agonism or antagonism evidenced from functional experiments is also commented. For some compounds, possible therapeutic applications are considered.
Non peptidic ligands at the opioid receptor like-1 (ORL-1) / D. Barlocco, L. Toma, G. Cignarella. - In: MINI-REVIEWS IN MEDICINAL CHEMISTRY. - ISSN 1389-5575. - 1:4(2001), pp. 363-375. [10.2174/1389557013406657]
Non peptidic ligands at the opioid receptor like-1 (ORL-1)
D. BarloccoPrimo
;G. Cignarella
2001
Abstract
Opioid receptor like-1 (ORL-1) has recently been indicated as a potentially useful target for the treatment of a number of central disorders and several other diseases. This review deals with non peptidic ligands at the ORL-1 receptor, focusing on their structural and binding properties. Agonism or antagonism evidenced from functional experiments is also commented. For some compounds, possible therapeutic applications are considered.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
