Starting from the commercially available (S)-1-phenylethylamine, we have synthesised the homochiral hydrazonoyl chlorides 4. The intramolecular cycloaddition of the corresponding nitrile imines 5 gave the diastereoisomeric 3,3a-dihydro-pyrazolo[ 1,5-a][1,4]benzodiazepine-6(4H)-ones 6 and 7 in enantiopure form. (C) 1999 Elsevier Science Ltd. All rights reserved.
Stereoselective intramolecular cycloadditions of homochiral nitrile imines: synthesis of enantiomerically pure 3,3a-dihydro-pyrazolo[1,5-a][1,4] benzodiazepine-6(4H)-ones / G. Broggini, L. Garanti, G. Molteni, T. Pilati, A. Ponti, G. Zecchi. - In: TETRAHEDRON. - ISSN 0040-4020. - 10:11(1999), pp. 2203-2212.
Stereoselective intramolecular cycloadditions of homochiral nitrile imines: synthesis of enantiomerically pure 3,3a-dihydro-pyrazolo[1,5-a][1,4] benzodiazepine-6(4H)-ones
G. Molteni;
1999
Abstract
Starting from the commercially available (S)-1-phenylethylamine, we have synthesised the homochiral hydrazonoyl chlorides 4. The intramolecular cycloaddition of the corresponding nitrile imines 5 gave the diastereoisomeric 3,3a-dihydro-pyrazolo[ 1,5-a][1,4]benzodiazepine-6(4H)-ones 6 and 7 in enantiopure form. (C) 1999 Elsevier Science Ltd. All rights reserved.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
