Abstract The authors studied the effects of major depression on lymphocyte subsets by comparing depressed and matched control subjects in a population of HIV-seropositive outpatients not treated with antiretroviral therapy. Twelve patients with major depression, as determined by the Structured Clinical Interview for DSM-III-R, were assessed in comparison with 15 matched nondepressed control subjects. Flow cytometric analysis of peripheral blood lymphocyte subsets together with immunological parameters were performed. In HIV-infected patients, major depression was significantly (P=0.001) associated with a reduction in natural killer cell absolute count and percentage. This report suggests that depression may alter the natural killer cell population that provides a cytotoxic defense against HIV infection.

Changes in lymphocyte subsets in depressed HIV-infected patients without antiretroviral therapy. / A. Alciati, A. Ferri, S. Rozi, A. d’Arminio Monforte, F. Colmegna, I. Valli, C. Mellado.. - In: PSYCHOSOMATICS. - ISSN 0033-3182. - 42:3(2001 May), pp. 247-251.

Changes in lymphocyte subsets in depressed HIV-infected patients without antiretroviral therapy.

A. Alciati
Primo
;
A. d’Arminio Monforte;
2001-05

Abstract

Abstract The authors studied the effects of major depression on lymphocyte subsets by comparing depressed and matched control subjects in a population of HIV-seropositive outpatients not treated with antiretroviral therapy. Twelve patients with major depression, as determined by the Structured Clinical Interview for DSM-III-R, were assessed in comparison with 15 matched nondepressed control subjects. Flow cytometric analysis of peripheral blood lymphocyte subsets together with immunological parameters were performed. In HIV-infected patients, major depression was significantly (P=0.001) associated with a reduction in natural killer cell absolute count and percentage. This report suggests that depression may alter the natural killer cell population that provides a cytotoxic defense against HIV infection.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/187573
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