Septic shock is mainly characterized by systemic hypotension, pulmonary hypertension and acute lung injury probably due to an involvement of inducible nitric oxide synthase (iNOS). Because previous works have evidenced that administration of LPS (20 microng/kg/h i.v. for 240 min) failed to induce iNOS expression, in this study we tested the effects of a double dose of LPS in 2 groups of anesthetized, tracheostomized and mechanically ventilated Large White pigs. Besides main cardiovascular parameters (systemic and pulmonary arterial pressures, cardiac output and heart rate), we evaluated also the NO in expired air and iNOS expression in bronchial epithelium and pulmonary parenchyma. Results evidenced that double doses of LPS cause the same cardiovascular effects obtained with dose of 20 microng/kg/h, but in this case there was presence of NO in the expired air and the expression of iNOS in lung tissue was evident

Coinvolgimento polmonare e vascolare dell’ossido d’azoto nello shock endotossico nel suino / S. Mazzola, M. Albertini, S. Grande, S. Radice. - In: ATTI DELLA SOCIETA' ITALIANA DELLE SCIENZE VETERINARIE. - ISSN 1721-1980. - 54(2000), pp. 77-78. ((Intervento presentato al 54. convegno LIV Congresso SISVet tenutosi a Riva del Garda (TN) nel 2000.

Coinvolgimento polmonare e vascolare dell’ossido d’azoto nello shock endotossico nel suino

S. Mazzola
Primo
;
M. Albertini
Secondo
;
S. Radice
2000

Abstract

Septic shock is mainly characterized by systemic hypotension, pulmonary hypertension and acute lung injury probably due to an involvement of inducible nitric oxide synthase (iNOS). Because previous works have evidenced that administration of LPS (20 microng/kg/h i.v. for 240 min) failed to induce iNOS expression, in this study we tested the effects of a double dose of LPS in 2 groups of anesthetized, tracheostomized and mechanically ventilated Large White pigs. Besides main cardiovascular parameters (systemic and pulmonary arterial pressures, cardiac output and heart rate), we evaluated also the NO in expired air and iNOS expression in bronchial epithelium and pulmonary parenchyma. Results evidenced that double doses of LPS cause the same cardiovascular effects obtained with dose of 20 microng/kg/h, but in this case there was presence of NO in the expired air and the expression of iNOS in lung tissue was evident
Settore VET/02 - Fisiologia Veterinaria
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/187499
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact