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A set of 1α/1β-[(4-R-phenyl)ethyl]quinolizidines was synthetized and together with selected intermediates was tested for affinity to sigma-1 receptor. Some compounds displayed good affinity for the relevant receptor, with Ki in the nanomolar range, and good selectivity versus σ2, 5-HT2A and D2 receptor subtypes.

Quinolizidine derivatives as ligands for sigma receptors / A. Sparatore, F. Novelli, F. Sparatore. - In: MEDICINAL CHEMISTRY RESEARCH. - ISSN 1054-2523. - 11:1(2002), pp. 1-11.

Quinolizidine derivatives as ligands for sigma receptors

A. Sparatore
Primo
;
2002

Abstract

A set of 1α/1β-[(4-R-phenyl)ethyl]quinolizidines was synthetized and together with selected intermediates was tested for affinity to sigma-1 receptor. Some compounds displayed good affinity for the relevant receptor, with Ki in the nanomolar range, and good selectivity versus σ2, 5-HT2A and D2 receptor subtypes.
1alpha [(4 phenyl)ethyl]quinolizidine derivative; 1alpha [(4 styryl)ethyl]quinolizidine derivative; 1beta [(4 phenyl)ethyl]quinolizidine derivative; 1beta [(4 styryl)ethyl]quinolizidine derivative; dopamine 2 receptor; ligand; phenyl group; quinolizidine derivative; receptor subtype; serotonin 2A receptor; sigma 1 opiate receptor; sigma opiate receptor;
Settore CHIM/08 - Chimica Farmaceutica
2002
Article (author)
01 - Articolo su periodico
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/187486
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