A set of 1α/1β-[(4-R-phenyl)ethyl]quinolizidines was synthetized and together with selected intermediates was tested for affinity to sigma-1 receptor. Some compounds displayed good affinity for the relevant receptor, with Ki in the nanomolar range, and good selectivity versus σ2, 5-HT2A and D2 receptor subtypes.
Quinolizidine derivatives as ligands for sigma receptors / A. Sparatore, F. Novelli, F. Sparatore. - In: MEDICINAL CHEMISTRY RESEARCH. - ISSN 1054-2523. - 11:1(2002), pp. 1-11.
Quinolizidine derivatives as ligands for sigma receptors
A. SparatorePrimo
;
2002
Abstract
A set of 1α/1β-[(4-R-phenyl)ethyl]quinolizidines was synthetized and together with selected intermediates was tested for affinity to sigma-1 receptor. Some compounds displayed good affinity for the relevant receptor, with Ki in the nanomolar range, and good selectivity versus σ2, 5-HT2A and D2 receptor subtypes.
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