Two reactive sequences of the pre-S regions of hepatitis B surface antigen were synthesized chemically and used in micro-ELISAs for the assay of pre-S1 and pre-S2 antigens in serum from patients with acute and chronic hepatitis B. Pre-S1 antigen correlated well with the presence of HBV-DNA and was no longer detectable on cessation of viral replication, after natural recovery and after successful treatment with alpha-interferon. Pre-S2 proteins were also lost after treatment with alpha-interferon. The results show that the assay of pre-S1 and pre-S2 proteins in serum provides additional useful markers for assessing patients with acute and chronic hepatitis B infection and for monitoring the response to treatment with interferon.
Pre-S proteins in hepatiti B / L. KUIJPERS, M. KOENS, I. MURRAY-LYON, J.C. COLEMAN, P. KARYANNIS, H. THOMAS, A.R. ZANETTI, A. CARGNEL, T.J. HARRISON, A.J. ZUCKERMAN. - In: JOURNAL OF MEDICAL VIROLOGY. - ISSN 0146-6615. - 28:1(1989), pp. 47-51.
|Titolo:||Pre-S proteins in hepatiti B|
|Settore Scientifico Disciplinare:||Settore MED/42 - Igiene Generale e Applicata|
|Data di pubblicazione:||1989|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/jmv.1890280111|
|Appare nelle tipologie:||01 - Articolo su periodico|