Antibodies against hepatitis C virus (anti-HCV) were detected in 60.8% of 78 patients with hepatocellular carcinoma (HCC). Cirrhosis, present in most of the patients, as well as alcohol abuse, age, sex, and α-fetoprotein were equally distributed in the anti-HCV-postitive and -negative groups. HBsAg positivity was significatively higher in negative anti-HCV group. By contrast, hepatitis B virus (HBV) antibodies were detected more frequently in positive anti-HCV patients than in the negative anti-HCV group. These data must be considered with caution because of the small number of HBsAg-positive patients. It is concluded that the high prevalence of anti-HCV in patients with HCC may suggest an etiological role of the hepatitis C virus, although in relationship to age, alcohol abuse and cirrhosis, the similarity in the two groups questions this hypothesis.

Serum antibodies to hepatitis C virus in italian patients with hepatocellular carcinoma / G. SBOLLI, A.R. ZANETTI, E. TANZI, L. CAVANNA, G. CIVARDI, F. FORNARI, M. DI STASI, L. BUSCARINI. - In: JOURNAL OF MEDICAL VIROLOGY. - ISSN 0146-6615. - 30:3(1990), pp. 230-232.

Serum antibodies to hepatitis C virus in italian patients with hepatocellular carcinoma

A.R. ZANETTI
Secondo
;
E. TANZI;
1990

Abstract

Antibodies against hepatitis C virus (anti-HCV) were detected in 60.8% of 78 patients with hepatocellular carcinoma (HCC). Cirrhosis, present in most of the patients, as well as alcohol abuse, age, sex, and α-fetoprotein were equally distributed in the anti-HCV-postitive and -negative groups. HBsAg positivity was significatively higher in negative anti-HCV group. By contrast, hepatitis B virus (HBV) antibodies were detected more frequently in positive anti-HCV patients than in the negative anti-HCV group. These data must be considered with caution because of the small number of HBsAg-positive patients. It is concluded that the high prevalence of anti-HCV in patients with HCC may suggest an etiological role of the hepatitis C virus, although in relationship to age, alcohol abuse and cirrhosis, the similarity in the two groups questions this hypothesis.
cirrhosis; hepatitis B virus; hepatitis C virus; hepatocellular carcinoma; non-A, non-B hepatitis viruses
Settore MED/42 - Igiene Generale e Applicata
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/187386
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