The complete definition of the chemical structure of GD1b-ganglioside (GD1b) lactone isolated from human brain has been given by means of spectrometric and spectroscopic analyses. GD1h lactone contains a single ester linkage involving the external sialic acid carboxyl group and the C-9 hydroxyl group of the internal sialic acid unit. A synthetic lactone of GD1b prepared treating GD1b with glacial acetic acid characterized in the same way showed an identical chemical structure.

GANGLIOSIDE LACTONES - H-1-NMR DETERMINATION OF THE INNER ESTER POSITION OF GD1B-GANGLIOSIDE LACTONE NATURALLY-OCCURRING IN HUMAN-BRAIN OR PRODUCED BY CHEMICAL SYNTHESIS / D. ACQUOTTI, G. FRONZA, L. RIBONI, S. SONNINO, G. TETTAMANTI. - In: GLYCOCONJUGATE JOURNAL. - ISSN 0282-0080. - 4:2(1987), pp. 119-127.

GANGLIOSIDE LACTONES - H-1-NMR DETERMINATION OF THE INNER ESTER POSITION OF GD1B-GANGLIOSIDE LACTONE NATURALLY-OCCURRING IN HUMAN-BRAIN OR PRODUCED BY CHEMICAL SYNTHESIS

L. RIBONI;S. SONNINO
Penultimo
;
G. TETTAMANTI
Ultimo
1987

Abstract

The complete definition of the chemical structure of GD1b-ganglioside (GD1b) lactone isolated from human brain has been given by means of spectrometric and spectroscopic analyses. GD1h lactone contains a single ester linkage involving the external sialic acid carboxyl group and the C-9 hydroxyl group of the internal sialic acid unit. A synthetic lactone of GD1b prepared treating GD1b with glacial acetic acid characterized in the same way showed an identical chemical structure.
ganglioside lactones; NMR
Settore BIO/10 - Biochimica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/187377
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