To investigate the activity of parenterally administered interferon-beta (IFN-beta) in women with genital human papillomavirus (HPV) infection, serum 2'-5'-oligoadenylate synthetase (2'-5'OAS), an enzyme induced by IFNs, was measured before, during, and after therapy. Serum levels of 2'-5'OAS significantly increased during therapy (P = .005). The patients classified as not responding to treatment at 3 months of follow-up had baseline levels of 2'-5'OAS significantly higher than those who responded to treatment (P = .0011). Differences between the IFN-beta-treated group and untreated controls appeared at day 6 (P = .0019). 2'-5'OAS is a useful parameter in monitoring parenterally administered IFN-beta. The data suggest that women with genital HPV infection and elevated baseline levels of 2'-5'OAS are unlikely to respond to therapy with IFN-beta.
Serum 2'-5'-oligoadenylate synthetase levels and clinical response to interferon-beta therapy in women with genital human papillomavirus infection / S. Rusconi, A. Agarossi, L. Ravasi, A. Tonta, M. Conti, M. Galli. - In: THE JOURNAL OF INFECTIOUS DISEASES. - ISSN 0022-1899. - 169:5(1994 May), pp. 1112-1115.
|Titolo:||Serum 2'-5'-oligoadenylate synthetase levels and clinical response to interferon-beta therapy in women with genital human papillomavirus infection|
RUSCONI, STEFANO (Primo)
GALLI, MASSIMO (Ultimo)
|Parole Chiave:||Humans ; Condylomata Acuminata ; Adult ; Interferon-beta ; Papillomaviridae ; Enzyme Induction ; 2',5'-Oligoadenylate Synthetase ; Middle Aged ; Follow-Up Studies ; Female|
|Settore Scientifico Disciplinare:||Settore MED/17 - Malattie Infettive|
|Data di pubblicazione:||mag-1994|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1093/infdis/169.5.1112|
|Appare nelle tipologie:||01 - Articolo su periodico|