The triglyceride-lowering effect of metformin (N,N-dimethylbiguanide) was tested in a series of patients with stable hypertriglyceridemia (types IIB, III and IV) and with variable degrees of glucose intolerance. Metformin caused a 38% mean decrease of plasma triglycerides. A selective decrease of very low density lipoprotein cholesterol was observed without reciprocal increase of low density lipoproteins. Thirty patients completed the study. Eighteen, who showed a hypotriglyceridemic effect exceeding 30%, were considered as "Responders"; the other 12, where the effect was negligible, were considered as "Non-Responder". Analysis of the pre-and post-treatment glucose tolerance tests of Responders and Non-Responders showed that the former had, on the average, a normal glucose tolerance and insulin secretion, whereas the latter had an impaired glucose tolerance with increased insulin secretion. These parameters were only slightly modified by metformin. The conclusions of this study support the hypothesis that biguanides exert a triglyceride-lowering effect by decreasing lipoprotein secretion, independent of changes in glucose tolerance and/or insulin secretion.

Treatment of hypertriglyceridemia with metformin. Effectiveness and analỳsis of results / C. R. Sirtori, E. Tremoli, M. Sirtori, F. Conti, R. Paoletti. - In: ATHEROSCLEROSIS. - ISSN 0021-9150. - 26:4(1977 Apr), pp. 583-592. [10.1016/0021-9150(77)90125-3]

Treatment of hypertriglyceridemia with metformin. Effectiveness and analỳsis of results

C. R. Sirtori;E. Tremoli;R. Paoletti
1977-04

Abstract

The triglyceride-lowering effect of metformin (N,N-dimethylbiguanide) was tested in a series of patients with stable hypertriglyceridemia (types IIB, III and IV) and with variable degrees of glucose intolerance. Metformin caused a 38% mean decrease of plasma triglycerides. A selective decrease of very low density lipoprotein cholesterol was observed without reciprocal increase of low density lipoproteins. Thirty patients completed the study. Eighteen, who showed a hypotriglyceridemic effect exceeding 30%, were considered as "Responders"; the other 12, where the effect was negligible, were considered as "Non-Responder". Analysis of the pre-and post-treatment glucose tolerance tests of Responders and Non-Responders showed that the former had, on the average, a normal glucose tolerance and insulin secretion, whereas the latter had an impaired glucose tolerance with increased insulin secretion. These parameters were only slightly modified by metformin. The conclusions of this study support the hypothesis that biguanides exert a triglyceride-lowering effect by decreasing lipoprotein secretion, independent of changes in glucose tolerance and/or insulin secretion.
Age Factors; Hyperlipidemias; Humans; Metformin; Drug Resistance; Cholesterol; Blood Glucose; Body Weight; Drug Evaluation; Triglycerides; Adult; Lipoproteins, VLDL; Middle Aged; Female; Male
Settore BIO/14 - Farmacologia
ATHEROSCLEROSIS
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/187249
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