In 18 anaesthetised and mechanically ventilated pigs, we analysed the activity of NG-nitro-L-arginine methyl ester (L-NAME) and of aminoguanidine respectively costitutive (cNOS) and inducible (iNOS) nitric oxide synthase inhibitors, in a model of septic shock induced by administration of E. Coli lipopolysaccharide (LPS). The evaluated parameters were: systemic (MAP) and pulmonary (MPAP) arterial pressure, cardiac output (CO), systemic (SVR) and pulmonary (PVR) vascular resistances and compliance (Crs) and resistance (Rrs) of the respiratory system. Results show that LPS increased the release of both cNOS and iNOS in the systemic vascular bed. cNOS exerted also a modulator activity in pulmonary vascular bed and reduced LPS bronchoconstrictor effect.

Ruolo dell’ossido d’azoto (NO) sul controllo broncomotore e vasomotore nello shock endotossico nel suino / M. Albertini, S. Mazzola. - In: ATTI DELLA SOCIETA' ITALIANA DELLE SCIENZE VETERINARIE. - ISSN 1721-1980. - 53(1999), pp. 43-44. ((Intervento presentato al 53. convegno LIII Congresso SISVet tenutosi a Montecatini Terme (PT) nel 1999.

Ruolo dell’ossido d’azoto (NO) sul controllo broncomotore e vasomotore nello shock endotossico nel suino

M. Albertini
Primo
;
S. Mazzola
Ultimo
1999

Abstract

In 18 anaesthetised and mechanically ventilated pigs, we analysed the activity of NG-nitro-L-arginine methyl ester (L-NAME) and of aminoguanidine respectively costitutive (cNOS) and inducible (iNOS) nitric oxide synthase inhibitors, in a model of septic shock induced by administration of E. Coli lipopolysaccharide (LPS). The evaluated parameters were: systemic (MAP) and pulmonary (MPAP) arterial pressure, cardiac output (CO), systemic (SVR) and pulmonary (PVR) vascular resistances and compliance (Crs) and resistance (Rrs) of the respiratory system. Results show that LPS increased the release of both cNOS and iNOS in the systemic vascular bed. cNOS exerted also a modulator activity in pulmonary vascular bed and reduced LPS bronchoconstrictor effect.
Settore VET/02 - Fisiologia Veterinaria
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/187235
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