Topical exposure to a variety of xenobiotics may result in irritant as well as allergic contact dermatitis both in rodents and in humans. Despite their induction by different mechanisms, they cannot be differentiated by macroscopic appearance and, by histological examination they are both generally characterized by a perivascular mononuclear cell infiltrate and capillary hyperpermeability. Recently, cytokines, a family of inducible glycoproteins that play a pivotal role in immune and inflammatory reactions, have been identified as useful tools for differentiation of irritant and allergic contact dermatitis. In this article the role of cytokines in the development and differentiation of irritant and allergic contact dermatitis is discussed.
Epidermal cytokines in experimental contact dermatitis / E. Corsini, C.L. Galli. - In: TOXICOLOGY. - ISSN 0300-483X. - 142:3(2000 Jan), pp. 203-211.
|Titolo:||Epidermal cytokines in experimental contact dermatitis|
CORSINI, EMANUELA (Primo)
GALLI, CORRADO LODOVICO (Ultimo)
|Parole Chiave:||Contact allergy; Contact dermatitis; Cytokines; Skin irritation|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||gen-2000|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/S0300-483X(99)00145-6|
|Appare nelle tipologie:||01 - Articolo su periodico|