KII ACE, the enzyme that converts angiotensin I and inactivates bradykinin, is highly concentrated in the lungs; its blockade reduces exposure to angiotensin II and enhances exposure to prostaglandins generated by local kinin hyperconcentration. Our hypothesis is that ACE inhibitors improve pulmonary function in chronic heart failure (CHF) by readjusting lung vessel tone and permeability or alveolar-capillary membrane diffusion.

Improvement of alveolar-capillary membrane diffusing capacity with enalapril in chronic heart failure and counteracting effect of aspirin / M. Guazzi, G. Marenzi, M. Alimento, M. Contini, P. Agostoni. - In: CIRCULATION. - ISSN 0009-7322. - 95:7(1997 Apr 01), pp. 1930-6-1936.

Improvement of alveolar-capillary membrane diffusing capacity with enalapril in chronic heart failure and counteracting effect of aspirin

M. Guazzi
Primo
;
P. Agostoni
Ultimo
1997

Abstract

KII ACE, the enzyme that converts angiotensin I and inactivates bradykinin, is highly concentrated in the lungs; its blockade reduces exposure to angiotensin II and enhances exposure to prostaglandins generated by local kinin hyperconcentration. Our hypothesis is that ACE inhibitors improve pulmonary function in chronic heart failure (CHF) by readjusting lung vessel tone and permeability or alveolar-capillary membrane diffusion.
Respiratory Function Tests; Heart Failure; Peptidyl-Dipeptidase A; Bradykinin; Double-Blind Method; Humans; Hydralazine; Cyclooxygenase Inhibitors; Isosorbide Dinitrate; Aged; Blood-Air Barrier; Pulmonary Circulation; Pulmonary Gas Exchange; Exercise Test; Enalapril; Aspirin; Epoprostenol; Angiotensin-Converting Enzyme Inhibitors; Middle Aged; Diffusion; Pulmonary Alveoli; Male; Female; Hypertension
Settore MED/11 - Malattie dell'Apparato Cardiovascolare
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/187181
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