4-Chloro-3-(hydroxymethyl)pyridine was prepared and isolated as its hydrochloride in 85% yield from 4-chloropyridine by formylation with dimethylformamide of the corresponding 3-lithium salt, followed by in situ reduction of the resulting 4-chloro-3-formylpyridine through a crossed-Cannizzaro reaction with aqueous formaldehyde.
Titolo: | A practical synthesis of 4-chloro-3-(hydroxymethyl)pyridine by regioselective one-pot lithiation/formylation/reduction of 4-chloropyridine |
Autori: | ALBANESE, DOMENICO (Primo) |
Parole Chiave: | 4-chloro-3- formylpyridine; 4-Chloro-3-hydroxymethylpyridine; Aromatic formylation; Crossed Cannizzaro reaction; Regioselective lithiation |
Settore Scientifico Disciplinare: | Settore CHIM/04 - Chimica Industriale |
Data di pubblicazione: | 1999 |
Rivista: | |
Tipologia: | Article (author) |
Appare nelle tipologie: | 01 - Articolo su periodico |
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