The expression of the p53 gene product was investigated immunocytochemically in a retrospective series of 164 formalin-fixed paraffin-embedded invasive breast carcinomas with pathologically proven negative lymph nodes. Overall, 78 tumors (48%) showed a variable degree of p53 immunoreactivity. Among these, 38 cases were low expressors (1-10%p53 immunoreactive tumor cells), 21 moderate expressors (10-50% immunoreactive cells) and 19 high expressors (> 50% immunoreactive cells). Abnormal p53 expression correlated significantly with tumor size, histological and nuclear grade, DNA ploidy, mitotic rate and proliferation index, and with the lack of estrogen receptors. Disease-free and adjusted survival analysis of the 124 node-negative patients with long term (more than 10 years) follow-up, however, did not reveal an independent prognostic role for p53 expression. These data suggest that the evaluation of p53 immunoreactivity may only play a role in a multiparametric prognostic assessment of node-negative breast carcinoma.
Abnormal p53 immunoreactivity and prognosis in node-negative breast carcinomas with long-term follow-up / S. Bosari, A. K. Lee, G. Viale, G. J. Heatley, G. Coggi. - In: VIRCHOWS ARCHIV. A, PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY. - ISSN 0174-7398. - 421:4(1992), pp. 291-295.
|Titolo:||Abnormal p53 immunoreactivity and prognosis in node-negative breast carcinomas with long-term follow-up|
BOSARI, SILVANO (Primo)
|Parole Chiave:||Tumor Suppressor Protein p53; Humans; Prognosis; Breast Neoplasms; Ploidies; Tumor Markers, Biological; Immunohistochemistry; Female|
|Settore Scientifico Disciplinare:||Settore MED/08 - Anatomia Patologica|
|Data di pubblicazione:||1992|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/BF01660975|
|Appare nelle tipologie:||01 - Articolo su periodico|