We investigated the presence of human T-lymphotropic virus type 2 (HTLV- 2) DNA in the peripheral blood mononuclear cell subsets obtained from 18 patients coinfected with human immunodeficiency virus type 1 and HTLV-2, 6 of whom also had predominantly sensory polyneuropathy (PSP). HTLV-2 DNA and RNA were found in CD8- and CD19-positive cells, and, for patients with PSP, in CD14-positive cells as well. Furthermore, the patients with PSP had higher proviral loads than those without PSP.

Human T-lymphotropic virus type 2 (HTLV-2) provirus in circulating cells of the monocyte/macrophage lineage in patients dually infected with human immunodeficiency virus type 1 and HTLV-2 and having predominantly sensory polyneuropathy / G. Zehender, L. Meroni, S. Varchetta, C. De Maddalena, B. Cavalli, M. Gianotto, A. B. Bosisio, C. Colasante, G. Rizzardini, M. Moroni, M. Galli. - In: JOURNAL OF VIROLOGY. - ISSN 0022-538X. - 72:9(1998 Sep), pp. 7664-7668.

Human T-lymphotropic virus type 2 (HTLV-2) provirus in circulating cells of the monocyte/macrophage lineage in patients dually infected with human immunodeficiency virus type 1 and HTLV-2 and having predominantly sensory polyneuropathy

G. Zehender;C. De Maddalena;C. Colasante;M. Moroni;M. Galli
1998-09

Abstract

We investigated the presence of human T-lymphotropic virus type 2 (HTLV- 2) DNA in the peripheral blood mononuclear cell subsets obtained from 18 patients coinfected with human immunodeficiency virus type 1 and HTLV-2, 6 of whom also had predominantly sensory polyneuropathy (PSP). HTLV-2 DNA and RNA were found in CD8- and CD19-positive cells, and, for patients with PSP, in CD14-positive cells as well. Furthermore, the patients with PSP had higher proviral loads than those without PSP.
Sensitivity and Specificity; HTLV-II Infections; Macrophages; Human T-lymphotropic virus 2; Humans; RNA, Viral; HIV-1; Evaluation Studies as Topic; Polymerase Chain Reaction; DNA, Viral; Peripheral Nervous System Diseases; AIDS-Related Opportunistic Infections; Adult; Mathematical Computing; Middle Aged; Monocytes; Deltaretrovirus Antibodies; Proviruses; Female; Male; T-Lymphocyte Subsets
Settore MED/17 - Malattie Infettive
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/186993
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