The isothiazole ring as well as the corresponding benzo- and heterocondensed rings are present in many chemically interesting compounds. The isothiazole ring can be a substituent of a bioactive scaffold or the pharmacophore of bioactive molecules. New compounds have been designed, synthesised and tested towards different biological targets and, in many cases, they display interesting pharmaceutical activities. Different SAR studies are reported starting from already known isothiazole derivatives or from new compounds characterised by a particular substitution pattern aiming to improve the biological activity. Agrochemical applications are also reported.

Chemistry of biologically active isothiazoles / F. Clerici, M.L. Gelmi, S. Pellegrino, D. Pocar (TOPICS IN HETEROCYCLIC CHEMISTRY). - In: Bioactive heterocycles III[s.l] : Springer, 2007. - ISBN 31: 3661936136. - pp. 179-264

Chemistry of biologically active isothiazoles

F. Clerici
Primo
;
M.L. Gelmi
Secondo
;
S. Pellegrino
Penultimo
;
D. Pocar
Ultimo
2007

Abstract

The isothiazole ring as well as the corresponding benzo- and heterocondensed rings are present in many chemically interesting compounds. The isothiazole ring can be a substituent of a bioactive scaffold or the pharmacophore of bioactive molecules. New compounds have been designed, synthesised and tested towards different biological targets and, in many cases, they display interesting pharmaceutical activities. Different SAR studies are reported starting from already known isothiazole derivatives or from new compounds characterised by a particular substitution pattern aiming to improve the biological activity. Agrochemical applications are also reported.
Settore CHIM/06 - Chimica Organica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/186928
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