Pulmonary function abnormalities participate in causing exercise disability in patients with congestive heart failure (CHF). Impaired pulmonary gas transfer is one of these abnormalities. Angiotensin-converting enzyme (ACE) inhibitors improve diffusion for carbon monoxide and exercise capacity, an effect that is seemingly mediated through prostaglandin activation because it is inhibited by cyclooxygenase blockade with aspirin. This suggests the possibility that aspirin may disturb the pulmonary function and exercise ability in CHF, at least in those patients who are taking ACE inhibitors. This study was aimed at probing this hypothesis.

Aspirin worsens exercise performance and pulmonary gas exchange in patients with heart failure who are taking angiotensin-converting enzyme inhibitors / M. Guazzi, G. Pontone, P. Agostoni. - In: AMERICAN HEART JOURNAL. - ISSN 0002-8703. - 138:2 Pt 1(1999 Aug), pp. 254-60-260. [10.1016/S0002-8703(99)70109-2]

Aspirin worsens exercise performance and pulmonary gas exchange in patients with heart failure who are taking angiotensin-converting enzyme inhibitors

M. Guazzi
Primo
;
P. Agostoni
Ultimo
1999

Abstract

Pulmonary function abnormalities participate in causing exercise disability in patients with congestive heart failure (CHF). Impaired pulmonary gas transfer is one of these abnormalities. Angiotensin-converting enzyme (ACE) inhibitors improve diffusion for carbon monoxide and exercise capacity, an effect that is seemingly mediated through prostaglandin activation because it is inhibited by cyclooxygenase blockade with aspirin. This suggests the possibility that aspirin may disturb the pulmonary function and exercise ability in CHF, at least in those patients who are taking ACE inhibitors. This study was aimed at probing this hypothesis.
Drug Interactions; Heart Failure; Humans; Cyclooxygenase Inhibitors; Aged; Hemodynamics; Pulmonary Gas Exchange; Enalapril; Spirometry; Aspirin; Angiotensin-Converting Enzyme Inhibitors; Exercise Tolerance; Middle Aged; Female; Male
Settore MED/11 - Malattie dell'Apparato Cardiovascolare
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/186783
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