The effect of melatonin injection evaluated earlier with respect to placebo-treated controls is reevaluated, also with reference to spontaneous changes in natural killer cell activity. This effect consists, first, of stimulation of natural killer cell activity over and above any changes brought about by placebo (saline). After 6 h, the melatonin effect appears to be an inhibition as compared to values from placebo-treated subjects, or no effect as compared to values from untreated subjects. In this case, amplification and attenuation of the placebo effect by melatonin are found within the relatively short span of 1/4 of a day, rather than within a day or a week. An ultradian 'feed-sideward' by melatonin may be aligned with the corresponding previously reported circadian and infradian chronomodulation.

Ultradian chronomodulation by melatonin of a Placebo effect upon human killer cell activity / P. Lissoni, O. Marelli, R. Mauri, M. Resentini, P. Franco, D. Esposti, G. Esposti, F. Fraschini, F. Halberg, R. B. Sothern. - In: CHRONOBIOLOGIA. - ISSN 0390-0037. - 13:4(1986), pp. 339--343.

Ultradian chronomodulation by melatonin of a Placebo effect upon human killer cell activity

O. Marelli;P. Franco;F. Fraschini;
1986

Abstract

The effect of melatonin injection evaluated earlier with respect to placebo-treated controls is reevaluated, also with reference to spontaneous changes in natural killer cell activity. This effect consists, first, of stimulation of natural killer cell activity over and above any changes brought about by placebo (saline). After 6 h, the melatonin effect appears to be an inhibition as compared to values from placebo-treated subjects, or no effect as compared to values from untreated subjects. In this case, amplification and attenuation of the placebo effect by melatonin are found within the relatively short span of 1/4 of a day, rather than within a day or a week. An ultradian 'feed-sideward' by melatonin may be aligned with the corresponding previously reported circadian and infradian chronomodulation.
Cytotoxicity, Immunologic; Circadian Rhythm; Killer Cells, Natural; Humans; Activity Cycles; Chronobiology Phenomena; Sodium Chloride; Placebos; Melatonin; Male
Settore BIO/14 - Farmacologia
CHRONOBIOLOGIA
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/186775
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