Week 48 HIV-RNA treatment response to the protease inhibitor tipranavir co-administered with ritonavir was compared with that of lopinavir co-administered with ritonavir in patients whose baseline isolates had varying lopinavir genotypic mutation scores. With increasing lopinavir mutation scores, the proportion of patients achieving a week 48 treatment response was increased in the tipranavir/ritonavir compared with the lopinavir/ritonavir arm. Tipranavir/ritonavir therapy improves treatment response rates compared with lopinavir/ritonavir in patients whose viruses have reduced susceptibility to lopinavir/ritonavir.
Treatment response to ritonavir-boosted tipranavir versus ritonavir-boosted lopinavir in HIV-1 patients with higher lopinavir mutation scores / S. L. Walmsley, L. Cotte, S. Rusconi, D. J. Ward, C. B. Hicks, U. Meier, H. Valdez, C. A. Boucher. - In: AIDS. - ISSN 0269-9370. - 21:16(2007 Oct 18), pp. 2245-8-2248.
Titolo: | Treatment response to ritonavir-boosted tipranavir versus ritonavir-boosted lopinavir in HIV-1 patients with higher lopinavir mutation scores |
Autori: | |
Parole Chiave: | Drug Administration Schedule; HIV Protease Inhibitors; Pyrones; Clinical Trials, Phase III as Topic; Humans; Pyridines; RNA, Viral; HIV-1; Viral Load; Drug Resistance, Viral; Lopinavir; Ritonavir; HIV Infections; Pyrimidinones; Treatment Outcome; Antiretroviral Therapy, Highly Active; HIV Protease; Mutation |
Settore Scientifico Disciplinare: | Settore MED/17 - Malattie Infettive |
Data di pubblicazione: | 18-ott-2007 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1097/QAD.0b013e3282ef6db7 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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00002030-200710180-00017 AIDS 2007.pdf | Publisher's version/PDF | Open Access Visualizza/Apri |