Week 48 HIV-RNA treatment response to the protease inhibitor tipranavir co-administered with ritonavir was compared with that of lopinavir co-administered with ritonavir in patients whose baseline isolates had varying lopinavir genotypic mutation scores. With increasing lopinavir mutation scores, the proportion of patients achieving a week 48 treatment response was increased in the tipranavir/ritonavir compared with the lopinavir/ritonavir arm. Tipranavir/ritonavir therapy improves treatment response rates compared with lopinavir/ritonavir in patients whose viruses have reduced susceptibility to lopinavir/ritonavir.

Treatment response to ritonavir-boosted tipranavir versus ritonavir-boosted lopinavir in HIV-1 patients with higher lopinavir mutation scores / S. L. Walmsley, L. Cotte, S. Rusconi, D. J. Ward, C. B. Hicks, U. Meier, H. Valdez, C. A. Boucher. - In: AIDS. - ISSN 0269-9370. - 21:16(2007 Oct 18), pp. 2245-8-2248.

Treatment response to ritonavir-boosted tipranavir versus ritonavir-boosted lopinavir in HIV-1 patients with higher lopinavir mutation scores

S. Rusconi;
2007

Abstract

Week 48 HIV-RNA treatment response to the protease inhibitor tipranavir co-administered with ritonavir was compared with that of lopinavir co-administered with ritonavir in patients whose baseline isolates had varying lopinavir genotypic mutation scores. With increasing lopinavir mutation scores, the proportion of patients achieving a week 48 treatment response was increased in the tipranavir/ritonavir compared with the lopinavir/ritonavir arm. Tipranavir/ritonavir therapy improves treatment response rates compared with lopinavir/ritonavir in patients whose viruses have reduced susceptibility to lopinavir/ritonavir.
Drug Administration Schedule; HIV Protease Inhibitors; Pyrones; Clinical Trials, Phase III as Topic; Humans; Pyridines; RNA, Viral; HIV-1; Viral Load; Drug Resistance, Viral; Lopinavir; Ritonavir; HIV Infections; Pyrimidinones; Treatment Outcome; Antiretroviral Therapy, Highly Active; HIV Protease; Mutation
Settore MED/17 - Malattie Infettive
Article (author)
File in questo prodotto:
File Dimensione Formato  
00002030-200710180-00017 AIDS 2007.pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 128.29 kB
Formato Adobe PDF
128.29 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/186754
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 11
  • ???jsp.display-item.citation.isi??? 6
social impact