Mouse leukemia, L1210, strongly enhances its immunogenicity following in vivo treatment with 5-(3-3'-dimethyl-1-triazeno) imidazole-4-carboxamide (DTIC). Previous experiments have shown that transformed cells elicit a cell-mediated response accountable for rejection and resistance to a subsequent injection of parental tumor into a syngeneic host. L1210 expresses classical H-2 class I molecules, and since it has been shown that DTIC treatment does not modify the expression of these molecules, this is a suitable model to study nonclassical class I antigens, such as Qa2 glycoproteins, and their potential role in tumorigenicity.
Down regulation of Qa gene expression on drug-modified tumor cells / E. Leroy, D. Lattuada, C. Casnici, P. Franco, O. Marelli. - In: TUMORI. - ISSN 0300-8916. - 79:6(1993 Dec 31), pp. 439-443.
Titolo: | Down regulation of Qa gene expression on drug-modified tumor cells | |
Autori: | LATTUADA, DONATELLA FRANCESCA (Secondo) FRANCO, PAOLA (Penultimo) MARELLI, ORNELLA (Ultimo) | |
Parole Chiave: | Animals ; Dacarbazine; Mice ; Mice, Inbred BALB C ; Gene Expression Regulation, Leukemic ; Leukemia L1210 ; Mice, Inbred DBA; Down-Regulation ; Tumor Cells, Cultured; Fluorescent Antibody Technique ; Female ; Male ; Genes, MHC Class I | |
Settore Scientifico Disciplinare: | Settore BIO/14 - Farmacologia | |
Data di pubblicazione: | 31-dic-1993 | |
Rivista: | ||
Tipologia: | Article (author) | |
Appare nelle tipologie: | 01 - Articolo su periodico |