The effects of erythromycin on the immune system have been studied in healthy volunteers and patients suffering from chronic bronchopneumonial diseases, by means of the following assays: phagocytosis, natural killer activity and superoxide anion production. The tests were performed before and after oral administration of 1 g of erythromycin. The findings suggest that erythromycin enhances phagocytosis by means of increasing ingestion of microorganisms, superoxide anion (O2-) production as well as natural killer activity. Under the experimental conditions described these effects appear 4-6 h after drug intake and reach their maximum around the 8th hour.
Evaluation of the immunostimulating activity of erythromycin in man / F. Fraschini, F. Scaglione, F. Ferrara, O. Marelli, P. C. Braga, F. Teodori. - In: CHEMOTHERAPY. - ISSN 0009-3157. - 32:3(1986), pp. 286-90-290.
Evaluation of the immunostimulating activity of erythromycin in man
F. Fraschini;F. Scaglione;O. Marelli;P. C. Braga;
1986
Abstract
The effects of erythromycin on the immune system have been studied in healthy volunteers and patients suffering from chronic bronchopneumonial diseases, by means of the following assays: phagocytosis, natural killer activity and superoxide anion production. The tests were performed before and after oral administration of 1 g of erythromycin. The findings suggest that erythromycin enhances phagocytosis by means of increasing ingestion of microorganisms, superoxide anion (O2-) production as well as natural killer activity. Under the experimental conditions described these effects appear 4-6 h after drug intake and reach their maximum around the 8th hour.
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