The effects of erythromycin on the immune system have been studied in healthy volunteers and patients suffering from chronic bronchopneumonial diseases, by means of the following assays: phagocytosis, natural killer activity and superoxide anion production. The tests were performed before and after oral administration of 1 g of erythromycin. The findings suggest that erythromycin enhances phagocytosis by means of increasing ingestion of microorganisms, superoxide anion (O2-) production as well as natural killer activity. Under the experimental conditions described these effects appear 4-6 h after drug intake and reach their maximum around the 8th hour.
|Titolo:||Evaluation of the immunostimulating activity of erythromycin in man|
|Parole Chiave:||Killer Cells, Natural; Humans; Adult; Superoxides; Middle Aged; Chronic Disease; Phagocytosis; Erythromycin; Male; Female; Bronchopneumonia|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||1986|
|Digital Object Identifier (DOI):||10.1159/000238425|
|Appare nelle tipologie:||01 - Articolo su periodico|