Recent research has found that entry of non-syncytium-inducing (NSI), monocyte-macrophage-tropic HIV-1 isolates requires binding to both CD4 and CCR5 receptors, and that delta 32/delta 32 homozygous individuals are protected against infection.

Homozygous delta 32 deletion of the CCR-5 chemokine receptor gene in an HIV-1-infected patient / C. Balotta, P. Bagnarelli, M. Violin, A. L. Ridolfo, D. Zhou, A. Berlusconi, S. Corvasce, M. Corbellino, M. Clementi, M. Clerici, M. Moroni, M. Galli. - In: AIDS. - ISSN 0269-9370. - 11:10(1997 Aug), pp. F67-71.

Homozygous delta 32 deletion of the CCR-5 chemokine receptor gene in an HIV-1-infected patient

C. Balotta
Primo
;
M. Violin;S. Corvasce;M. Clerici;M. Moroni
Penultimo
;
M. Galli
Ultimo
1997-08

Abstract

Recent research has found that entry of non-syncytium-inducing (NSI), monocyte-macrophage-tropic HIV-1 isolates requires binding to both CD4 and CCR5 receptors, and that delta 32/delta 32 homozygous individuals are protected against infection.
Polymorphism, Genetic; Humans; Receptors, CCR5; Immunity, Innate; Receptors, HIV; Sequence Analysis, DNA; HIV-1; Italy; Cloning, Molecular; Polymerase Chain Reaction; HIV Envelope Protein gp120; Receptors, Cytokine; HIV Seropositivity; Risk Factors; European Continental Ancestry Group; Heterozygote; Adult; Cohort Studies; Viremia; Mutation; Male; Sequence Deletion
Settore MED/17 - Malattie Infettive
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/186673
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