Ofuji's disease, also known as 'eosinophilic pustular folliculitis', is a rare inflammatory skin disorder of unknown aetiology, which affects mostly adult Japanese males. Only few Caucasian patients have been described so far. We report the case of a 44-year-old Italian woman with Ofuji's disease who had circulating antibodies against the recombinant envelope glycoprotein (Rgp46I) of HTLV-1. By means of a very sensitive nested PCR, the tax region of HTLV-1, but not other regions, was found in peripheral blood mononuclear cells. Our observations suggest that a retrovirus, closely related to HTLV but not yet identified, could be involved in the pathogenesis of the disease in this patient.
Evidence of retroviral involvement in an Italian patient with Ofuji's disease / S. Veraldi, P. Ferrante, R. Mancuso, R. Gianotti, R. Caputo. - In: DERMATOLOGY. - ISSN 1018-8665. - 198:1(1999), pp. 86-89.
|Titolo:||Evidence of retroviral involvement in an Italian patient with Ofuji's disease|
VERALDI, STEFANO (Primo)
GIANOTTI, RAFFAELE (Penultimo)
|Parole Chiave:||Polymerase Chain Reaction; DNA, Viral; Humans; Eosinophils; Retroviridae; Adult; Retroviridae Infections; Italy; Folliculitis; Female|
|Settore Scientifico Disciplinare:||Settore MED/35 - Malattie Cutanee e Veneree|
Settore MED/17 - Malattie Infettive
|Data di pubblicazione:||1999|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1159/000018073|
|Appare nelle tipologie:||01 - Articolo su periodico|