The chemical synthesis of disaccharides 1 and 2, useful building-blocks for the preparation of a new series of heparin related oligosaccharides containing the unusual sequence (GlcN-IdoA)(n), is described. In addition, the orthogonality of the protective groups would allow access to a wide array of differently sulfated oligosaccharides. As the simplest members of this new class of oligomer, the synthesis of sulfated disaccharides 3 and 4 fully deprotected is reported. (C) 1999 Elsevier Science Ltd. All rights reserved.
Synthesis of disaccharidic sub-units of a new series of heparin related oligosaccharides / B. La Ferla, L. Lay, M. Guerrini, L. Poletti, L. Panza, G. Russo. - In: TETRAHEDRON. - ISSN 0040-4020. - 55:32(1999), pp. 9867-9880.
Titolo: | Synthesis of disaccharidic sub-units of a new series of heparin related oligosaccharides |
Autori: | LAY, LUIGI (Secondo) |
Parole Chiave: | carbohydrates; glycosidation; biologically active compounds; sulfonation |
Settore Scientifico Disciplinare: | Settore CHIM/06 - Chimica Organica |
Data di pubblicazione: | 1999 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/S0040-4020(99)00526-8 |
Appare nelle tipologie: | 01 - Articolo su periodico |