A family of five regioisomenc protected fucosyllactoses has been synthesised in only 14 overall steps from the easily available benzyllactoside. The adopted strategy combines enzymatic regioselective protection, introduction of ortho-gonal protecting groups and regioselective glycosylations on partially unprotected lactosidic acceptors.
Lipase-catalysed regioselective acylations in combination with regioselective glycosylations as a strategy for the synthesis of oligosaccharides: Synthesis of a series of fucosyllactose building blocks / A. Rencurosi, L. Poletti, G. Russo, L. Lay. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - 2003:9(2003), pp. 1672-1680.
Titolo: | Lipase-catalysed regioselective acylations in combination with regioselective glycosylations as a strategy for the synthesis of oligosaccharides: Synthesis of a series of fucosyllactose building blocks |
Autori: | POLETTI, LAURA (Secondo) RUSSO, GIOVANNI (Penultimo) LAY, LUIGI (Corresponding) |
Parole Chiave: | oligosaccharides ; fucosyllactose ; glycosylation ; lipase acylation |
Settore Scientifico Disciplinare: | Settore CHIM/06 - Chimica Organica |
Data di pubblicazione: | 2003 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/ejoc.200200425 |
Appare nelle tipologie: | 01 - Articolo su periodico |