The simplified synthesis of a portion of Globo-H hexasaccharide, a saccharide antigen overexpressed by breast cancer cells, and its conjugation to two different immunogenic proteins are described, The conjugated vaccines, evaluated in a preclinical model, showed good immunogenic potential.

Improvement of the synthesis of immunological carbohydrate vaccines containing the tumour associate antigen CaMBr1 / L. Lay, L. Panza, L. Poletti, D. Prosperi, S. Canevari, M.E. Perico. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - :22(2001), pp. 4331-4336. [10.1002/1099-0690(200111)2001:22<4331::AID-EJOC4331>3.0.CO;2-R]

Improvement of the synthesis of immunological carbohydrate vaccines containing the tumour associate antigen CaMBr1

L. Lay
Primo
;
L. Poletti;
2001

Abstract

The simplified synthesis of a portion of Globo-H hexasaccharide, a saccharide antigen overexpressed by breast cancer cells, and its conjugation to two different immunogenic proteins are described, The conjugated vaccines, evaluated in a preclinical model, showed good immunogenic potential.
carbohydrates conjugate vaccine ; CRM197 ; Globo-H ; KLH
Settore CHIM/06 - Chimica Organica
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/186206
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