Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by the triad of recurrent thrombosis, fetal losses and thrombocytopenia associated with phospholipid binding proteins. The syndrome is a rare example of an autoimmune disease in which the diagnostic autoantibodies are also pathogenic. Owing to the widespread distribution of the target antigens, autoantibodies can interfere with coagulation homeostasis as well as with placentation sustaining the thrombophilia and the miscarriages, respectively. Recent advances in etiology and pathogenesis are changing the knowledge the treatment of the syndrome.
Pathogenic mechanisms of antiphospholipid syndrome : a new autoimmune disease / P. Meroni, P. Riboldi. - In: DRUG DISCOVERY TODAY: DISEASE MECHANISMS. - ISSN 1740-6765. - 1:3(2004), pp. 309-314. [10.1016/j.ddmec.2004.11.006]
Pathogenic mechanisms of antiphospholipid syndrome : a new autoimmune disease
P. MeroniPrimo
;P. RiboldiUltimo
2004
Abstract
Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by the triad of recurrent thrombosis, fetal losses and thrombocytopenia associated with phospholipid binding proteins. The syndrome is a rare example of an autoimmune disease in which the diagnostic autoantibodies are also pathogenic. Owing to the widespread distribution of the target antigens, autoantibodies can interfere with coagulation homeostasis as well as with placentation sustaining the thrombophilia and the miscarriages, respectively. Recent advances in etiology and pathogenesis are changing the knowledge the treatment of the syndrome.
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