Cellular and molecular mechanisms mediating the effect of polychlorinated biphenyls on oocyte in vitro maturation: Polychlorinated biphenyls (PCBs) are stable, lipophilic compounds that accumulate in the environment and in the food chain. Recent studies provide evidence that exposure to PCBs can cause reproductive problems. PCBs have been identified in the ovarian follicle of women and other mammals and many data in the literature clearly indicate that both follicles and oocytes are particularly susceptible to these pollutants. In the present review we describe the multifaceted effects of PCBs on mammalian oocyte maturation in detail. Published studies clearly indicate that PCB congeners, both singly or as complex mixtures, disrupt mammalian oocyte maturation and subsequent embryo development. Specifically, data point out to the ability of PCBs to interfere with the organization of the microtubules cytoplasmic network resulting in an altered compartmentalization of the ooplasm. Furthermore, a critical role of cumulus cells in mediating PCB ovotoxicity has been observed, most likely related to a disregulation in intracellular communication between the germinal and the somatic compartment. Finally, since coplanar PCBs, induce gene expression via a ligand-dependent transactivating factor, the aryl hydrocarbon receptor, this signalling pathway is also reviewed with respect to understanding the toxic mechanisms of these compounds.
Cellular and molecular mechanisms mediating the effect of polychlorinated biphenyls on oocyte in vitro maturation / P. Pocar, T.A.L. Brevini, S. Antonini, F. Gandolfi. - In: REPRODUCTIVE TOXICOLOGY. - ISSN 0890-6238. - 22:2(2006), pp. 242-249.
|Titolo:||Cellular and molecular mechanisms mediating the effect of polychlorinated biphenyls on oocyte in vitro maturation|
POCAR, PAOLA (Primo)
ANTONINI, STEFANIA (Penultimo)
GANDOLFI, FULVIO (Ultimo)
|Parole Chiave:||Polychlorinated biphenyls (PCBs); Oocyte; In vitro maturation|
|Settore Scientifico Disciplinare:||Settore VET/01 - Anatomia degli Animali Domestici|
|Data di pubblicazione:||2006|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.reprotox.2006.04.023|
|Appare nelle tipologie:||01 - Articolo su periodico|