Activity of p53, H-ras, c-myc and c-fos in psoriatic lesions was studied using monoclonal antibodies (MoAbs) performing a sensitive immunohistochemical method on frozen sections. Normal skin from surgery was used as control. Reactivity of p53, H-ras and c-myc is remarkable in psoriatic plaques but, in contrast, c-fos expression does not show differences compared to control skin. These findings led us to speculate about the importance of cellular oncogenes in the pathogenesis of psoriasis.
P53 and oncogenes expression in psoriasis / G. Tadini, A. Cerri, L. Crosti, G. Cattoretti, E. Berti. - In: ACTA DERMATO-VENEREOLOGICA. SUPPLEMENTUM. - ISSN 0365-8341. - 146:146(1989), pp. 33-5-35.
P53 and oncogenes expression in psoriasis
A. CerriSecondo
;E. Berti
1989
Abstract
Activity of p53, H-ras, c-myc and c-fos in psoriatic lesions was studied using monoclonal antibodies (MoAbs) performing a sensitive immunohistochemical method on frozen sections. Normal skin from surgery was used as control. Reactivity of p53, H-ras and c-myc is remarkable in psoriatic plaques but, in contrast, c-fos expression does not show differences compared to control skin. These findings led us to speculate about the importance of cellular oncogenes in the pathogenesis of psoriasis.
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