We evaluated free plasma levels of protein S, a natural anticoagulant factor, the prevalence of anti-protein S antibodies, a possible cause of protein S deficiency, and their correlation with anti-phospholipid antibodies in 53 patients with inflammatory bowel disease (IBD) and 53 age- and sex-matched controls. Mean free plasma protein S levels (± SD) were significantly lower in IBD patients (0.98 ± 0.32 IU/ml) than in controls (1.06 ± 0.28 IU/ml) (P < 0.05); only one patient showed protein S deficiency. Specific antibodies to protein S were found in four IBD patients (7.5%) and in one control (1.9%) (P = NS). Five IBD patients (9.4%) and none of the controls showed anti-phospholipid antibodies (P < 0.06). No correlation was found between free protein S levels and anti-protein S antibodies or between anti-protein S and anti-phospholipid antibodies. In conclusion, free plasma protein S levels are slightly but significantly decreased in IBD patients. The prevalence of anti-protein S and antiphospholipid antibodies is increased in IBD patients. Anti-protein S antibodies do not appear to determine low protein S levels or to overlap with or belong to anti-phospholipid antibodies.
Reduced free protein S levels in patients with inflammatory bowel disease - Prevalence, clinical relevance, and role of anti-protein S antibodies / S. Saibeni, M. Vecchi, C. Valsecchi, E. Faioni, C. Razzari, R. De Franchis. - In: DIGESTIVE DISEASES AND SCIENCES. - ISSN 0163-2116. - 46:3(2001), pp. 637-643.
|Titolo:||Reduced free protein S levels in patients with inflammatory bowel disease - Prevalence, clinical relevance, and role of anti-protein S antibodies|
VECCHI, MAURIZIO (Secondo)
|Parole Chiave:||Antibodies; Inflammatory bowel disease; Protein S; Thrombosis|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
Settore MED/12 - Gastroenterologia
|Data di pubblicazione:||2001|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1023/A:1005675921664|
|Appare nelle tipologie:||01 - Articolo su periodico|