The developmental profiles of the gangliosides and those of the fatty acids and long-chain bases of the total ganglioside mixture of the brain of chicken were followed from the 10th day of incubation to the 63rd posthatching day. One O-acetylated polysialoganglioside that seems specific of the earlier embryonic stage and up to 21 alkali-stable components could be recognized by high-resolution two-dimensional TLC procedures and quantified by computer-assisted two-dimensional TLC densitometry. Besides a number of gangliosides identified by co-chromatography with reference standards, 10 were of unidentified structure, and within these 4 did not belong to the gangliotetrahexosyl series. Throughout embryonic life, the ceramide portion of gangliosides was found to contain the long-chain base species with 18 carbons. Those with 20 carbons, ~10% of the total, were found to be present only after hatching.
FURTHER-STUDIES ON THE CHANGES OF CHICKEN BRAIN GANGLIOSIDES DURING PRENATAL AND POSTNATAL LIFE / S. SONNINO, R. BASSI, V. CHIGORNO, G. TETTAMANTI. - In: JOURNAL OF NEUROCHEMISTRY. - ISSN 0022-3042. - 54:5(1990), pp. 1653-1660.
|Titolo:||FURTHER-STUDIES ON THE CHANGES OF CHICKEN BRAIN GANGLIOSIDES DURING PRENATAL AND POSTNATAL LIFE|
SONNINO, SANDRO (Primo)
BASSI, ROSARIA (Secondo)
CHIGORNO, VANNA LUIGIA (Penultimo)
TETTAMANTI, GUIDO (Ultimo)
|Parole Chiave:||Age; Brain; Development; Fatty acids; Gangliosides; Long-chain bases|
|Settore Scientifico Disciplinare:||Settore BIO/10 - Biochimica|
|Data di pubblicazione:||1990|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1111/j.1471-4159.1990.tb01218.x|
|Appare nelle tipologie:||01 - Articolo su periodico|