The developmental profiles of the gangliosides and those of the fatty acids and long-chain bases of the total ganglioside mixture of the brain of chicken were followed from the 10th day of incubation to the 63rd posthatching day. One O-acetylated polysialoganglioside that seems specific of the earlier embryonic stage and up to 21 alkali-stable components could be recognized by high-resolution two-dimensional TLC procedures and quantified by computer-assisted two-dimensional TLC densitometry. Besides a number of gangliosides identified by co-chromatography with reference standards, 10 were of unidentified structure, and within these 4 did not belong to the gangliotetrahexosyl series. Throughout embryonic life, the ceramide portion of gangliosides was found to contain the long-chain base species with 18 carbons. Those with 20 carbons, ~10% of the total, were found to be present only after hatching.

FURTHER-STUDIES ON THE CHANGES OF CHICKEN BRAIN GANGLIOSIDES DURING PRENATAL AND POSTNATAL LIFE / S. SONNINO, R. BASSI, V. CHIGORNO, G. TETTAMANTI. - In: JOURNAL OF NEUROCHEMISTRY. - ISSN 0022-3042. - 54:5(1990), pp. 1653-1660.

FURTHER-STUDIES ON THE CHANGES OF CHICKEN BRAIN GANGLIOSIDES DURING PRENATAL AND POSTNATAL LIFE

S. SONNINO
Primo
;
R. BASSI
Secondo
;
V. CHIGORNO
Penultimo
;
G. TETTAMANTI
Ultimo
1990

Abstract

The developmental profiles of the gangliosides and those of the fatty acids and long-chain bases of the total ganglioside mixture of the brain of chicken were followed from the 10th day of incubation to the 63rd posthatching day. One O-acetylated polysialoganglioside that seems specific of the earlier embryonic stage and up to 21 alkali-stable components could be recognized by high-resolution two-dimensional TLC procedures and quantified by computer-assisted two-dimensional TLC densitometry. Besides a number of gangliosides identified by co-chromatography with reference standards, 10 were of unidentified structure, and within these 4 did not belong to the gangliotetrahexosyl series. Throughout embryonic life, the ceramide portion of gangliosides was found to contain the long-chain base species with 18 carbons. Those with 20 carbons, ~10% of the total, were found to be present only after hatching.
Age; Brain; Development; Fatty acids; Gangliosides; Long-chain bases
Settore BIO/10 - Biochimica
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/185789
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 22
  • ???jsp.display-item.citation.isi??? 26
social impact