We carried out a highly stereoselective Michael addn. (96% de) of nitromethane to enantiomerically pure tricarbonyl(ethyl-4-chloro-2-trimethylsilylcinnamate)chromium(0). This reaction is the key step in the synthesis of (R)-(-)-baclofen, a potent antispastic drug
Michael addition of nitromethane to non-racemic chiral Cr(CO)3 complexes of ethyl cinnamate derivatives: stereoselective synthesis of (R)-(-)-baclofen / C. Baldoli, S. Maiorana, E. Licandro, D. Perdicchia, B. Vandoni. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 11:9(2000), pp. 2007-2014. [10.1016/S0957-4166(00)00123-3]
Michael addition of nitromethane to non-racemic chiral Cr(CO)3 complexes of ethyl cinnamate derivatives: stereoselective synthesis of (R)-(-)-baclofen
S. MaioranaSecondo
;E. Licandro;D. PerdicchiaPenultimo
;
2000
Abstract
We carried out a highly stereoselective Michael addn. (96% de) of nitromethane to enantiomerically pure tricarbonyl(ethyl-4-chloro-2-trimethylsilylcinnamate)chromium(0). This reaction is the key step in the synthesis of (R)-(-)-baclofen, a potent antispastic drug
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