Ten patients with acute respiratory failure (ARF), (4 pneumonia, 4 sepsis, 2 polytrauma), underwent computerized tomography (CT) of the lungs, (apex, hilum, base), at 5, 10, 15 cm H2O positive end expiratory pressure (PEEP). The ARF lungs, on CT scan, appeared as a patchwork of normal and dense areas with generally well defined boundaries. Most of the densities were found in the dependent regions. The areas of density were correlated with PaO2 (r=0.51). The PEEP increase resulted in a significant expansion of total cross-sectional lung surface area. The dense areas decreased significantly at the hilum and base when increasing PEEP while the changes at the apex were not significant. The changes of density with PEEP were highly correlated with the changes in oxygenation (r=0.91). In the individual patient, however, the modifications of gas exchange can not be entirely predicted from morphological changes, possibly due to a diversion of pulmonary blood flow.
Morphological response to positive end expiratory pressure in acute respiratory failure : computerized tomography study / L. Gattinoni, D. Mascheroni, A. Torresin, R. Marcolin, R. Fumagalli, S. Vesconi, G. P. Rossi, F. Rossi, S. Baglioni, F. Bassi, G. Nastri, A. Pesenti. - In: INTENSIVE CARE MEDICINE. - ISSN 0342-4642. - 12:3(1986), pp. 137-142.
|Titolo:||Morphological response to positive end expiratory pressure in acute respiratory failure : computerized tomography study|
GATTINONI, LUCIANO (Corresponding)
PESENTI, ANTONIO (Ultimo)
|Parole Chiave:||Acute respiratory failure; CT scan; PEEP|
|Settore Scientifico Disciplinare:||Settore MED/41 - Anestesiologia|
|Data di pubblicazione:||1986|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/BF00254928|
|Appare nelle tipologie:||01 - Articolo su periodico|